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Ultimately, integrating multimodal biomarkerscombining neuroimaging, electrophysiology (Cardon et al., 2020), blood-based molecular profiles, and audiological measuresinto a composite model holds the greatest promise

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(1) Controlled-Release PHEN/TPM in Severely Obese Adults (EQUIP) trial (obesity without comorbidities), (2) Controlled-Release Phentermine plus Topiramate Combination in Overweight and Obese Adults (CONQUER) trial (obesity with comorbidities), and (3) SEQUEL (2-year extension of CONQUER), were comprised of 7% of older adult participants across the trials, although the upper age limit was 70 [111,112,113]